To boost immunity and prevent cancer
Activation of the patient’s own immune cells cultured and processed in vitro
Immunity” declines with age, which is said to increase the risk of developing various diseases such as viral infections and cancer. Super Premium Immunotherapy Therapy” is a treatment method that is expected to have anti-tumor effects by artificially strengthening the function of the immune system.
The patient’s own immune cells are cultured and processed outside the body to activate them, and then returned to the body for treatment. This treatment is clinically used as an advanced therapy that enables treatment while maintaining quality of life (Quality Of Life = QOL). Since your own cells are used, there is almost no rejection or side effects, so you can receive the treatment with peace of mind.
At our clinic, we are focusing on treatment methods using various types of immune cells, including NK cell immunotherapy. Our director, Dr. Eri Katagiri, who has abundant experience and knowledge as an internist, has partnered with a reputable laboratory that possesses the most advanced cell culture and processing technology to provide advanced treatments that will satisfy everyone so that patients can receive treatment with peace of mind.
What is Super Premium Immunotherapy/Therapy?
Personalized medicine” tailored to each individual is now possible.
Just as each person’s face is unique, the nature of cancer is completely different from patient to patient. On the other hand, there are various types of immune cells that attack cancer, and there are multiple types of immunotherapy (immuno-cell therapy) depending on the type of cells used for treatment.
We have prepared multiple treatment menus for different types of immune cells, such as NK cells, αβT cells, γδT cells, and dendritic cells. We are ready to provide “personalized medicine” to as many patients as possible by understanding the status of cancer cells and immune cells through counseling and proposing treatments accordingly.
Takahiro Ochiya, M.D., a world authority on cancer treatment research and regenerative medicine
Professor of Tokyo Medical University / medical doctor
Head of Molecular Cell Therapy Research Department, National Cancer Center Research Institute
Awards, etc.
- February 21, 2020
Received the Princess Takamatsu Cancer Research Fund Academic Award for “Establishment and Practical Application of Early Diagnosis of Cancer by MicroRNA in Body Fluid. - January 2020
Web of science announces the world’s most influential scientific researchers and names 2019 Highly Cited Researchers. - September 2017
He is the only Japanese researcher selected by the Nobel Committee as one of the 10 most notable researchers in the world and will give a special invited lecture.
About Takahiro Ochiya, M.D.
We are grateful to Professor Ochiya for his endorsement of our ” regenerative medicine stem cell therapy” and “super premium immunotherapy/therapy” for cancer and other preventive medicine, and for his cooperation as a consulting physician.
Why we are a qualified medical facility
- Officially obtained a regenerative medicine donation plan number from the Ministry of Health, Labour and Welfare
- Business alliance with a specified cell processing facility (FA3150001) compliant with the new law “Ensuring the Safety of Regenerative Medicine, etc.” with the highest level of safety and culture technology in Japan
- Director Eri Katagiri, who has extensive experience and knowledge as an internist, is able to provide “advanced treatment” based on an assessment of the patient’s health condition and constitution.
- The selection methods listed here are only examples. The decision will be made based on the eligibility test and a consultation with your physician.
Cancer prevention through immunotherapy and treatment
Cancer” caused by various influences
Cancer is believed to be caused by genetic damage from diet, smoking, viruses, bacteria, radiation, ultraviolet light, reactive oxygen species, and chemicals.
Among immune cells, “NK cell immunotherapy” enhances self-healing power by maximally activating NK cells, and is highly effective in treating and preventing the onset of cancer and viral infections as well as improving health.
It is known that low NK activity in the blood is associated with a high risk of cancer, and immunotherapy, including NK cells, is attracting a great deal of attention as a safe and ideal treatment.
4 Features of Immunotherapy
1. using your own cells, there are fewer side effects
Immunotherapy (immuno-cell therapy) uses the patient’s own immune cells for treatment, so it has almost no side effects other than a mild fever in some cases, and its greatest feature is that it is extremely easy on the body. The minimal side effects do not cause loss of physical strength, and treatment can be continued while maintaining QOL (quality of life).
Can be used in combination with other treatments and synergistic effects can be expected.
Immunotherapy (immuno-cell therapy) can be used in combination with other therapies, and synergistic effects can be expected depending on how they are combined. Recent studies have shown that by enhancing systemic immunity with immunotherapy (immuno-cell therapy), it is possible to improve the overall effectiveness of treatment without compromising the effectiveness of other treatments. Therefore, immunotherapy is also expected to serve as a foundation for the so-called three major cancer therapies (surgery, radiotherapy, and chemotherapy).
3. outpatient treatment, no need for hospitalization
The treatment itself is basically just blood sampling and intravenous infusion every two to three weeks, so there is no need for hospitalization and treatment can be done on an outpatient basis.
4. available for both early-stage and advanced cancer patients
Immunotherapy (immuno-cell therapy) is a gentle treatment that uses the body’s own cells, so it is available to patients in the early stages of cancer as well as those with advanced or recurrent cancer. It is also applicable to almost all types of cancer except for some hematological cancers.
- It depends on the type of treatment.
How Immuno-Cell Therapy Works
Immune cells are removed from the body by blood sampling, proliferated and activated by cell processing, and returned to the body. The cycle is repeated several times.
It is also expected to be effective as a preventive treatment for recurrence
Immunotherapy (immuno-cell therapy) is also considered suitable for recurrence prevention. As a treatment to prevent recurrence after surgery, immuno-cell therapy is characterized by its ability to prevent recurrence with little concern for side effects.
Results showing that immuno-cell therapy after surgery reduced recurrence and increased survival rates have been reported in prestigious foreign journals.
- Cancer Immunol Immunother” Kimura H, Matsui Y, Ishikawa A, Nakajima T, Yoshino M, Sakairi Y. Randomized controlled phase III trial of adjuvant chemo- Randomized controlled phase III trial of adjuvant chemo-immunotherapy with activated killer T cells and dendritic cells in patients with r esected primary lung cancer. Cancer Immunol Immunother. Epub 20 14 Sep 28.
- Takayama T, Sekine T, Makuuchi M, Yamasaki S, Kosuge T, Yamamoto J, Shimada K, Sakamoto M, Hirohashi S, Ohashi Y, Kakizoe T., Adoptive Makuuchi M, Yamasaki T, Sekine T, Makuuchi M, Kosuge T, Yamamoto J, Shimada K, Sakamoto M, Hiro S, Ohashi Y, Kakizoe T, Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial.
- Kimura H, Yamaguchi Y., A phase III randomized study of interleukin-2 lymphokine-activated killer cell immunotherapy combined with chemotherapy or radiotherapy after curative or noncurative resection of primary lung carcinoma. A phase III randomized study of interleukin-2 lymphokine-activated killer cell immunotherapy combined with chemotherapy or radiotherapy after curative or noncurative resection of primary lung carcinoma. Cancer. 80(1):42-9, 1997
Types of immune cells and their treatment
You can choose the treatment that is best for you.
NK cell therapy
NK cells: kill cancer as soon as they are detected.
It constantly patrols the body and when it finds cancer cells, it starts attacking and destroying them. This treatment stimulates immune cells, mainly NK cells contained in the peripheral blood, with IL-2 and other substances to activate and proliferate them and return them to the body.
Alpha-beta T-cell therapy (alpha-beta T-cell therapy)
Alpha beta T cells Work faithfully on command.
It can destroy cancer cells that carry the antigen. Mononuclear cells in the peripheral blood are cultured in the presence of anti-CD3 antibodies and IL-2 to activate and proliferate alpha-beta T cells, which are then returned to the body.
Gamma-delta T-cell therapy (gamma-delta T-cell therapy)
γδ T cells Antitumor action to fight cancer
It has a potent antitumor effect and eliminates even cancer cells that are hiding antigens. Lymphocytes isolated from peripheral blood are selectively cultured in the presence of zoledronic acid and IL-2 to activate and proliferate, and are then returned to the body.
Dendritic cell therapy
Dendritic cells Obtain information on the enemy and communicate the target of attack
Dendritic cells, also called antigen-presenting cells, are like gatekeepers. Dendritic cells are responsible for quickly identifying antigens and transmitting this information to helper T cells to trigger an immune response. In this method, dendritic cells, which are differentiated from monocytes in the peripheral blood, take up their target cancer cells and return them to the body. It is hoped that the dendritic cells will present antigens in the body, thereby inducing cancer cell-specific CTLs.
Side Effects
Immuno-cell therapy is basically a minimally invasive treatment that is administered by drawing and administering blood and can be performed as an outpatient. It is safe and has only minor side effects, although mild fever may occur. *
- Kamigaki T. et al., Anticance “Res. 2014: 34 (8): 4601-7”
For those who are not eligible for treatment
For the safety of our patients, we have established the following criteria for the implementation of regenerative medicine at our clinic. Patients who fall under any of these categories are not eligible to receive treatment. Please be aware of this.
- Those with positive test results for infectious diseases
1-1. Patients who test positive for HIV and HTLV-1 antibodies
1-2. Patients with T-cell and NK-cell derived malignant lymphomas and leukemias - Have received an organ or allogeneic transplant
- Persons with active autoimmune disease
- Age under 16 years old
- Pregnant women – nursing mothers
- Inability to consent or inability to obtain consent from a substitute
- The patient has not received a written explanation of consent for this treatment and has not given his/her free and voluntary consent in writing (if the surrogate has not given his/her consent in writing).
- When the doctor in charge judges that it is not indicated by interview, examination, etc.
Examples of immunotherapy/therapy
Immune enhancement and cancer prevention
First, the eligibility test!
Eligibility Tests and Counseling
remedy
NK cell therapy
Eliminate cancer as soon as you find it.
alpha-beta T-cell therapy
(Alpha and beta T cells)
Work faithfully to the mandate.
Have had cancer in the past
First, the eligibility test!
Eligibility Tests and Counseling
remedy
NK cell therapy
Eliminate cancer as soon as you find it.
alpha-beta T-cell therapy
(Alpha and beta T cells)
Work faithfully to the mandate.
gamma-delta T-cell therapy
(gamma-delta T cells)
Anti-tumor action to fight cancer
Dendritic cell therapy
(Artificial antigen peptide)
Obtain enemy intelligence and communicate attack targets
Treatment Flow
initial medical examination
The physician in charge will provide counseling, explain the treatment, and ask you to fill out a consent form.
drawing blood
The first blood sample will be drawn. The amount and method of blood collection depends on the treatment.
cell culture
The cells are cultured for approximately 2 to 3 weeks. (The number of culture days will vary depending on the cell type.)
prescribing medicine
Cultured and activated immune cells are administered. The site of administration can be intravascular or subcutaneous/intradermal.
observation
Visit the clinic approximately 2 to 3 weeks after the initial administration for follow-up.
medical treatment
As a general rule, a course of six sessions is performed once every two to three weeks.
Charge
First time only
| (data) item | Fee (JPY, excl. VAT) |
|---|---|
| Immune function test (qualification test) | 50,000 |
| counseling | 15,000 |
- In addition to the above, additional testing fees will be charged depending on the eligibility test to be conducted. Even if the results of the tests show that the patient is not eligible for treatment, the test fee will still be charged.
Price List
| (data) item | Fee (JPY, excl. VAT) |
|---|---|
| NK cell therapy | 1 time 600,000 6 times (1 course) 3,000,000 |
| alpha-beta T-cell therapy alpha-beta T cell | 1 time 400,000 6 times (1 course) 2,000,000 |
| gamma-delta T-cell therapy gamma-delta T cell | 1 time 500,000 6 times (1 course) 2,500,000 |
| Dendritic cell therapy | 1 time 300,000 6 times (1 course) 1,500,000 |
| Artificial antigenic peptides | 17,000 per type |
- Dendritic cell therapy requires additional antigen peptide usage.
- Prices vary depending on the combination of peptides used.
If freezing and thawing after culture is necessary, the above fee will be charged separately from the treatment fee per specimen.
| (data) item | Fee (JPY, excl. VAT) |
|---|---|
| Cell cryopreservation fee | 50,000 |
| Freezing and thawing fee | 50,000 |
- The cryopreservation period for cell carriers collected for dendritic cell therapy treatment is one year from the date of blood collection.
- The cryopreservation period for cells collected for treatment of various lymphocyte therapies is 6 months from the date of blood collection.
- Even if the patient cancels the treatment for his/her own reason, he/she will be responsible for the cost of the cell processing since the cell processing has already started.
- Please note that due to the nature of cellular immunotherapy, even if you are unable to come to the hospital on the day of your infusion appointment due to weather or traffic conditions, we will not be able to postpone or cancel your appointment.
- All of the above fees are only applicable to patients who present a valid Japanese health insurance card, are fluent in Japanese, and have no difficulty with counseling. For other patients, please refer to the estimate after the consultation.
