Use supernatant fluid derived from deciduous teeth that is rich in cytokines
Our Stem Cell Therapy Philosophy
We offer “deciduous dental pulp stem cell culture and supernatant therapy” using the latest medical technology, which is the ultimate anti-aging treatment, to improve the constitution and rejuvenate the whole body. The human body is composed of approximately 60 trillion cells, and stem cells are the base of these cells, which have the ability to differentiate (transform) into various types of cells and replicate themselves.
In recent years, regenerative medicine using the power of stem cells has been attracting increasing attention in the field of cosmetic medicine, but it has been difficult to maintain high quality, hygiene, and safety. Dr. Eri Katagiri uses pulp stem cell culture supernatant produced at a facility affiliated with a laboratory with the highest level of technology in Japan that is recognized as safe in the stem cell and cell culture process, in order to ensure that patients can receive treatment with peace of mind above all else, not to mention the cosmetic medical effects. We use the supernatant produced at the affiliated facility.
Regenerative Medicine Stem Cell* Therapy
- Use of healthy cells with an average age of less than 10 years
- Business alliance with a research institute that boasts Japan’s highest level of technology
- Establishing synergy with ERI Clinic Omotesando’s unique procedures and in-house prescriptions.
- The director himself handles all counseling and all procedures.
*Deciduous tooth pulp stem cell culture supernatant therapy with
Improvement of symptoms that can be expected
Various “anti-aging” effects in terms of beauty and health can be expected.
- Skin regeneration (wrinkles, spots, sagging, pores, various skin problems)
- AGA (Alopecia areata gravidarum)
- thinning hair
- diet
- stiff shoulders
- cervicobrachialgia
- relief from fatigue
- atopic dermatitis
- Various allergic diseases
- Athletes (muscle and immunity, etc.)
- dementia
- Parkinson’s disease prevention
*What are stem cells: The human body is composed of 60 trillion cells. Stem cells are the base cells of those cells. Stem cells have the ability to differentiate (transform) into various types of cells and to replicate themselves.
Super Premium Stem Cell Therapy Milk Teeth Dental Pulp Stem Cell Supernatant (“Exosome”) Therapy
Purified deciduous dental pulp stem cell cultures containing high-quality regenerative factors
Pulp cells are the nerves of the tooth in the central part of the tooth. They are guarded by the hard layer of the tooth, which makes them resistant to genetic damage and cancer, and they contain a large number of very healthy, high-quality stem cells.
Since stem cells are harvested from teeth and cultured, it is easier and safer than well-known methods of stem cell harvesting such as bone marrow or fat, with less burden and risk to the donor. In addition, stem cells tend to decrease rapidly with age, so it is best to manufacture stem cells from as young a source as possible, such as “baby teeth or wisdom teeth under 20 years old.
We use deciduous dental pulp stem cell culture supernatant, which is rich in more than 100 growth factors, cultured from “deciduous tooth” stem cells, which have extremely high cell proliferative capacity, under strict donor screening.
Major types of growth factors (cytokines) in deciduous dental pulp stem cell culture supernatant and their effects.
| Types of cytokines | Main effects |
|---|---|
| Vascular endothelial growth factor | VEGF Hair growth, hair growth |
| epidermal growth factor | EGF and its Family Blemishes, dullness, improvement of epidermal turnover, prevention of wrinkles |
| keratinocyte growth factor | KGF Hair growth, hair growth |
| insulin-like growth factor | IGF Skin regeneration, improvement of wrinkles, regeneration of elasticity such as firmness, hair growth |
| platelet-derived growth factor | PDGF Promotes cell division, proliferation and regeneration of damaged tissue |
| transforming growth factor | TGF-β, TGF-α and its Family Anti-inflammatory, wound healing |
| hepatocyte growth factor | HGF Tissue regeneration |
| Nervous system trophic factor CNTF (ciliary neurotrophic factor) | Promotion of neural stem cell proliferation and activity |
| Neurotrophic factor GDNF (glial cell line-derived neurotrophic factor) | Differentiation and growth of neurons, promotion of dopamine uptake |
| Nervous system trophic factor NGF (nerve growth factor) | Synthesize and promote neurotransmitters, maintain nerve cells, repair damaged cells, promote recovery of cranial nerve function and prevent aging, prevent Alzheimer’s disease and dementia |
| Nervous system trophic factor BDNF (brain-derived neurotrophic factor) | Maintain survival and promote growth of nerve cells, prevent Alzheimer’s disease and dementia |
| the rest |
About “Autologous Dental Pulp Stem Cells” and “Dental Pulp Cell Banks
Only one deciduous tooth or primary tooth can be preserved and cultured for more than 50 years
What are autologous dental pulp stem cells?
There are two types of pulp stem cell therapy: “autologous,” which uses primary teeth or third molars (wisdom teeth) of a blood relative, such as yourself, your children, or your grandchildren, and “alumni,” which uses primary teeth donated by others.
Advantages of Home
In the unlikely event that regenerative medicine becomes necessary due to illness or injury, it can be used to treat not only the patient but also his/her relatives. It can also be used to investigate the cause of an intractable disease and to treat it if it occurs in the future. The extracted dental pulp stem cells are cultured only for high quality cells, and can be stored in a specialized storage facility (dental pulp stem cell bank) for more than 50 years.
About the Dental Pulp Stem Cell Bank
We also offer the Pulp Stem Cell Bank® (culture and storage service of dental pulp cells), in which autologous dental pulp stem cells extracted from extracted teeth (deciduous teeth, wisdom teeth extracted for treatment, etc.) are stored in a specialized institution.
This is a service in which dental pulp cells, including high-quality stem cells from teeth, are cultured up to a certain amount and stored frozen at -150°C or lower for a long period of time at a cell storage facility using specialized freezing equipment. By storing even a single deciduous tooth, it is possible to produce a large amount of deciduous dental pulp stem cell culture supernatant that can be used not only by family members but also by relatives.
They may be useful for “peace of mind” in case of emergency for your family, children, or relatives, such as in the unlikely event that regenerative medicine is needed due to illness or injury. Those stem cells can also be used as our “Super Premium Stem Cell and Advanced Therapy”.
Flow of “Dental Pulp Stem Cell Bank” from application to storage
Tooth extractions at affiliated dental clinics
Sending extracted teeth to storage facility
If a baby tooth is about to fall out, please visit our affiliated dental clinic as soon as possible for extraction. (It is difficult to culture a tooth that has fallen out.)
Promptly received by the partner dental clinic to the storage facility to begin culturing
Upon confirmation of successful incubation, this contract
After the start of culture, upon confirmation of successful culture (approximately 2 weeks), you will be asked to sign a contract and pay the storage fee to the pulp stem cell storage company.
*No storage fee will be charged if the cells are not found to be culturing well after the start of culture.
Available anytime for clinic treatment
Studies have shown that pulp cells can generally be cultured in larger quantities than bone marrow or fat cells.
- The initial cost includes all fees such as registration, culture, testing, and multi-facility storage, but does not include fees for tooth extraction at the dentist’s office or culture during treatment.
- Cell culture may not be possible due to worsening decay or other reasons, but if it does not lead to storage, there is no charge at all.
- The time from extraction to storage takes one to two months. Progress reports will be provided by the storage facility in stages via e-mail or other means.
- Dental Pulp Cell Bank® is a registered trademark (Trademark No. 5891317) of Cell Technology, Inc.
Examples
Mesotherapy to the Face
Improvement of fine lines and pores
Improvement of texture and texture
Mesotherapy to the scalp
Improvement of thinning hair
Improvement of thinning hair
It is also effective for various allergic diseases, atopic dermatitis, cervical lumbago, dementia, Parkinson’s disease prevention, diet, stiff shoulders, athletes, etc.
Treatment Methods and Fees
<Autologous> Treatment of pulp stem cell culture supernatant of deciduous tooth
Administration: Mesotherapy, iontophoresis, intravenous infusion, nasal drip
| (data) item | Fee (JPY, excl. VAT) |
|---|---|
| 1ml x 30 vials (30 doses) | 3,500,000 |
| 1ml x 60 vials (60 doses) | 4,250,000 |
| 1ml x 90 vials (90 doses) | 5,000,000 |
| [Injection fee | 5,000 |
| [Anesthesia tape | 1 piece 500 |
| [Various intravenous infusions (if saline solution is desired) | 2,000 |
<Others> Treatment of deciduous tooth pulp stem cell culture supernatant
Administration: Mesotherapy, iontophoresis, intravenous infusion, nasal drip
| Dosing Method | Fee (JPY, excl. VAT) |
|---|---|
| mesotherapy | 1 vial 80,000 2 vials 144,000 3 vials 192,000 |
| ion implantation | 1 vial 50,000 2 vials 90,000 3 vials 120,000 |
| intravenous drip | 1 vial 60,000 2 vials 108,000 3 vials 153,000 4 vials 192,000 5 vials 195,000 30 vials 810,000 |
| Inhalation (nebulizer) | 1 vial 80,000 |
| Nasal spray (home care) | 90,000 per bottle |
| undiluted solution (of) | 1 vial 50,000 10 vials 400,000 |
| [Injection fee | 5,000 |
| [Anesthesia tape | 1 piece 500 |
| [Various intravenous infusions (if saline solution is desired) | 2,000 |
Pulp cell storage registration fee
| (data) item | Fee (JPY, excl. VAT) |
|---|---|
| 10 years storage | [Initial registration fee] 600,000 [Registration renewal fee] 350,000 |
- The initial cost includes all fees such as registration, culture, testing, and multi-facility storage, but does not include fees for tooth extraction at the dentist’s office or culture during treatment.
- Cell culture may not be possible due to worsening decay or other reasons, but if it does not lead to storage, there is no charge at all.
- All of the above fees are only applicable to patients who present a valid Japanese health insurance card and who are fluent in Japanese and have no difficulty with the counseling process. For other patients, please refer to the estimate after the counseling.
Frequently Asked Questions
Why choose dental pulp among stem cells?
The main cell types used in stem cell therapy include those from dental pulp, bone marrow, cord blood, placenta, and fat. Placenta tends to be unsafe because the route of collection is unclear. In addition, most of the fat from other sources is used after liposuction, which is more likely to have diseases such as diabetes and hyperlipidemia, and the cells themselves tend to be aged. On the other hand, dental pulp stem cells have established donors and collection routes, and by carefully selecting specific cell culture laboratories, regenerative medicine using high-quality, extremely safe, and youthful cells is possible.
| Stem cell type | feature |
|---|---|
| pulp-derived stem cell | Donors and collection routes have been established, enabling regenerative medicine using high-quality, extremely safe, youthful cells with high growth factors. |
| bone marrow-derived stem cell | There is severe pain associated with the collection of the blood, and only a hematopoietic effect can be expected, making it suitable for use in the treatment of blood disorders such as leukemia and aplastic anemia. |
| umbilical cord blood-derived stem cell | The route of collection tends to be unclear and unsafe. In addition, only hematopoietic effects can be expected, making it suitable for use in the treatment of hematologic diseases such as leukemia and aplastic anemia. |
| placenta-derived stem cell | Collection routes are unclear and tend to be unsafe. |
| Adipose-derived stem cells (other family) | Many of the other families use post-liposuction fat, which is likely to have diseases such as diabetes and hyperlipidemia, and the cells themselves tend to age, so excessive effects cannot be expected. |
*In our “autologous fat-derived stem cell therapy,” stem cells extracted from your own fat (autologous) are cultured and injected for treatment.
What is the difference between PRP therapy (platelet-rich plasma) and PRP therapy?
PRP is the supernatant fluid obtained when blood is collected and centrifuged, and is not cultured. Therefore, unlike stem cell therapy, it contains almost no growth factors or cytokines and is not expected to have cell activation effects (risks of skin problems such as inflammation have also been reported).
